OSH2/YDL019C Summary Help

Standard Name OSH2 1
Systematic Name YDL019C
Feature Type ORF, Verified
Description Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH2 has a paralog, SWH1, that arose from the whole genome duplication (1, 2)
Name Description OxySterol binding protein Homolog 1
Chromosomal Location
ChrIV:421514 to 417663 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All OSH2 GO evidence and references
  View Computational GO annotations for OSH2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 87 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
63 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Biochemical Activity: 9
  • PCA: 4
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 5
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 17
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,283
Molecular Weight (Da) 145,795
Isoelectric Point (pI) 6.81
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:421514 to 417663 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3852 421514..417663 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002177
References cited on this page View Complete Literature Guide for OSH2
1) Beh CT, et al.  (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61