OSH2/YDL019C Summary

OSH2 BASIC INFORMATION

Standard Name	OSH2
Systematic Name	YDL019C
Feature Type	ORF, Verified
Description	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability (1)
Name Description	OxySterol binding protein Homolog 1

GO Annotations	All OSH2 GO evidence and references
	View Computational GO annotations for OSH2
Molecular Function
Manually curated	oxysterol binding (ISS) phosphatidylinositol binding (ISS)
Biological Process
Manually curated	endocytosis (IGI) exocytosis (IGI) maintenance of cell polarity (IGI) sterol transport (IGI)
Cellular Component
Manually curated	cellular bud neck (IDA) endoplasmic reticulum (IDA) plasma membrane (IDA)

Mutant Phenotype	All OSH2 Phenotype details and references
Classical genetics
null	resistance to nystatin: increased resistance to rapamycin: increased viable
Large-scale survey
null	glycogen accumulation: increased resistance to pyocyanin: decreased viable

Interactions	OSH2 All interactions details and references
	40 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Biochemical Activity: 9 PCA: 2 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Dosage Rescue: 1 Phenotypic Enhancement: 10 Synthetic Lethality: 1

Sequence Information

ChrIV:421512 to 417661 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3852	421512..417661	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002177

OSH2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for OSH2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for OSH2]

1)	Beh CT, et al. (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40

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