Standard Name	ORM2 1
Systematic Name	YLR350W
Feature Type	ORF, Verified
Description	Protein of unknown function; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication (1, 2, 3, 4)

Chromosomal Location	ChrXII:828730 to 829380 | ORF Map | GBrowse

	View Computational GO annotations for ORM2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular sphingolipid homeostasis (IMP) negative regulation of sphingolipid biosynthetic process (IGI, IMP) response to unfolded protein (IMP, ISS)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) SPOTS complex (IDA)
High-throughput	endoplasmic reticulum (IDA) integral to membrane (ISM)

Classical genetics
null	viable
overexpression	ceramide accumulation: decreased
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to camptothecin: increased resistance to bleomycin: increased resistance to mycophenolic acid: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to cycloheximide: decreased resistance to fenpropimorph: decreased resistance to dimethyl sulfoxide: decreased resistance to CTBT: decreased resistance to paromomycin: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	595 total interaction(s) for 370 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 2 Affinity Capture-Western: 10 Biochemical Activity: 8 PCA: 28 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 403 Phenotypic Enhancement: 17 Phenotypic Suppression: 16 Positive Genetic: 57 Synthetic Growth Defect: 18 Synthetic Lethality: 3 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:828730 to 829380 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..651 828730..829380 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004342