Standard Name	ORM1 1, 2
Systematic Name	YGR038W
Feature Type	ORF, Verified
Description	Protein of unknown function; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication (3, 4, 5)

Chromosomal Location	ChrVII:560682 to 561350 | ORF Map | GBrowse

	View Computational GO annotations for ORM1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular sphingolipid homeostasis (IMP) negative regulation of sphingolipid biosynthetic process (IGI, IMP, IPI) response to unfolded protein (IMP, ISS)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) SPOTS complex (IDA)
High-throughput	endoplasmic reticulum (IDA) integral to membrane (ISM)

Classical genetics
null	resistance to sirolimus: increased viable
overexpression	ceramide accumulation: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased resistance to methyl methanesulfonate: decreased resistance to boric acid: decreased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased sporulation: normal starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	100 total interaction(s) for 61 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-Western: 10 Biochemical Activity: 7 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 45 Phenotypic Enhancement: 3 Phenotypic Suppression: 4 Positive Genetic: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 2 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:560682 to 561350 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..669 560682..561350 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003270