Standard Name	OPT1 1
Systematic Name	YJL212C
Alias	HGT1 2 , GSH11 3
Feature Type	ORF, Verified
Description	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family (2, 4, 5)
Name Description	OligoPeptide Transporter 1

Chromosomal Location	ChrX:36249 to 33850 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for OPT1
Molecular Function
Manually curated	oligopeptide transporter activity (IMP) proton-dependent oligopeptide secondary active transmembrane transporter activity (IDA)
Biological Process
Manually curated	oligopeptide transport (IDA) sulfur compound metabolic process (IEP)
Cellular Component
Manually curated	integral to plasma membrane (IDA, IMP, ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	resistance to hygromycin B: decreased resistance to tellurite: increased
overexpression	carboxypeptidase Y (CPY) modification: delayed resistance to glutathione: decreased
Large-scale survey
null	auxotrophy glutathione excretion: increased competitive fitness: increased competitive fitness: decreased resistance to cycloheximide: decreased resistance to neomycin: decreased resistance to cadmium dichloride: decreased resistance to oleate: decreased resistance to ethanol: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	45 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 1 Protein-RNA: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 15 Phenotypic Enhancement: 1 Positive Genetic: 14 Synthetic Growth Defect: 2 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:36249 to 33850 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2400 36249..33850 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000003748