OPI1/YHL020C Summary Help

OPI1 BASIC INFORMATION

Standard Name OPI1
Systematic Name YHL020C
Feature Type ORF, Verified
Description Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance (1, 2, 3)
Name Description OverProducer of Inositol 4
GO Annotations All OPI1 GO evidence and references
    View Computational GO annotations for OPI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs OPI1 Transcription Factor Binding Sites and References
  • TCGAAYC
Regulatory modules predicted: cellcycle ( 215 )
Mutant Phenotype All OPI1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions OPI1 All interactions details and references
51 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 5
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 13
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3
  • Synthetic Rescue: 5
Sequence Information
ChrVIII:67453 to 66239 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1215 67453..66239 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001012

OPI1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for OPI1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for OPI1]

1) Sreenivas A and Carman GM  (2003) Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase A. J Biol Chem 278(23):20673-80
2) Santiago TC and Mamoun CB  (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30
3) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
4) Greenberg ML, et al.  (1982) Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol-excreting mutants. Genetics 100(1):19-33