OCT1/YKL134C Summary Help

Standard Name OCT1 1
Systematic Name YKL134C
Feature Type ORF, Verified
Description Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis (1, 2, 3)
Name Description OCTapeptidyl aminopeptidase 3
Gene Product Alias mitochondrial intermediate peptidase 2
Chromosomal Location
ChrXI:191442 to 189124 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All OCT1 GO evidence and references
  View Computational GO annotations for OCT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
Resources
67 total interaction(s) for 60 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 49
  • Positive Genetic: 7
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 772
Molecular Weight (Da) 88,183
Isoelectric Point (pI) 7.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:191442 to 189124 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2319 191442..189124 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001617
References cited on this page View Complete Literature Guide for OCT1
1) Branda SS, et al.  (1999) Mitochondrial intermediate peptidase and the yeast frataxin homolog together maintain mitochondrial iron homeostasis in Saccharomyces cerevisiae. Hum Mol Genet 8(6):1099-110
2) Isaya G, et al.  (1994) MIP1, a new yeast gene homologous to the rat mitochondrial intermediate peptidase gene, is required for oxidative metabolism in Saccharomyces cerevisiae. Mol Cell Biol 14(8):5603-16
3) Vogtle FN, et al.  (2011) Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization. Mol Biol Cell 22(13):2135-43