OAZ1/YPL052W Summary Help

Standard Name OAZ1 1
Systematic Name YPL052W
Alias YPL052W-A 1
Feature Type ORF, Verified
Description Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p (1, 2, 3)
Name Description Ornithine decarboxylase AntiZyme 1
Chromosomal Location
ChrXVI:458799 to 459678 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All OAZ1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 145 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
12 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 292
Molecular Weight (Da) 34,045
Isoelectric Point (pI) 7.07
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:458799 to 459678 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-12-14
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..207 458799..459005 2011-02-03 2005-12-14
Plus 1 translational frameshift 208..208 459006..459006 2011-02-03 2005-12-14
CDS 209..880 459007..459678 2011-02-03 2005-12-14
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005973
References cited on this page View Complete Literature Guide for OAZ1
1) Palanimurugan R, et al.  (2004) Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J 23(24):4857-67
2) Porat Z, et al.  (2008) Yeast Antizyme Mediates Degradation of Yeast Ornithine Decarboxylase by Yeast but Not by Mammalian Proteasome: NEW INSIGHTS ON YEAST ANTIZYME. J Biol Chem 283(8):4528-34
3) Kurian L, et al.  (2011) Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA.LID - 10.1038/nature10393 [doi] Nature ()