OAF1/YAL051W Summary

OAF1 BASIC INFORMATION

Standard Name	OAF1
Systematic Name	YAL051W
Alias	YAF1
Feature Type	ORF, Verified
Description	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis (1, 2)
Name Description	Oleate-Activated transcription Factor 3

GO Annotations	All OAF1 GO evidence and references
	View Computational GO annotations for OAF1
Molecular Function
Manually curated	DNA binding (IDA, IPI, ISS) transcription activator activity (IMP, IPI, ISS)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	fatty acid metabolic process (IGI, IMP) negative regulation of transcription (IMP) peroxisome organization (IGI, IMP) positive regulation of transcription (IGI, IMP, IPI)
Cellular Component
Manually curated	nucleus (IPI)

Mutant Phenotype	All OAF1 Phenotype details and references
Large-scale survey
null	resistance to oleate: decreased viable

Interactions	OAF1 All interactions details and references
	35 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Co-localization: 4 Reconstituted Complex: 3
Genetic Interactions	Phenotypic Enhancement: 4 Phenotypic Suppression: 11

Sequence Information

ChrI:48565 to 51708 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 2004-07-20

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3144	48565..51708	2004-07-20	2004-07-20

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000048

OAF1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for OAF1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for OAF1]

1)	Karpichev IV and Small GM (1998) Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Mol Cell Biol 18(11):6560-70
2)	Rottensteiner H, et al. (1997) A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur J Biochem 247(3):776-83
3)	Luo Y, et al. (1996) Purification, identification, and properties of a Saccharomyces cerevisiae oleate-activated upstream activating sequence-binding protein that is involved in the activation of POX1. J Biol Chem 271(20):12068-75

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