OAF1/YAL051W Summary Help

Standard Name OAF1 1
Systematic Name YAL051W
Alias YAF1
Feature Type ORF, Verified
Description Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; involved in diauxic shift; OAF1 has a paralog, PIP2, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Oleate-Activated transcription Factor 1
Chromosomal Location
ChrI:48564 to 51707 | ORF Map | GBrowse
Gene Ontology Annotations All OAF1 GO evidence and references
  View Computational GO annotations for OAF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 18 genes
Regulators 1 genes
Classical genetics
Large-scale survey
54 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-localization: 4
  • Reconstituted Complex: 3

Genetic Interactions
  • Negative Genetic: 20
  • Phenotypic Suppression: 1
  • Positive Genetic: 13

Expression Summary
Length (a.a.) 1,047
Molecular Weight (Da) 118,891
Isoelectric Point (pI) 6.98
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrI:48564 to 51707 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3144 48564..51707 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000048
References cited on this page View Complete Literature Guide for OAF1
1) Luo Y, et al.  (1996) Purification, identification, and properties of a Saccharomyces cerevisiae oleate-activated upstream activating sequence-binding protein that is involved in the activation of POX1. J Biol Chem 271(20):12068-75
2) Karpichev IV and Small GM  (1998) Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Mol Cell Biol 18(11):6560-70
3) Rottensteiner H, et al.  (1997) A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur J Biochem 247(3):776-83
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Zampar GG, et al.  (2013) Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast. Mol Syst Biol 9():651
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
7) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66