Standard Name	OAF1
Systematic Name	YAL051W
Alias	YAF1
Feature Type	ORF, Verified
Description	Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Oleate-Activated transcription Factor 4

Chromosomal Location	ChrI:48564 to 51707 | ORF Map | GBrowse

	View Computational GO annotations for OAF1
Molecular Function
Manually curated	contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular response to oleic acid (IPI) positive regulation of chromatin silencing at telomere (IMP) positive regulation of fatty acid beta-oxidation (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	nucleus (IPI)

Binding motifs	AWCYCCGR 5 [Search intergenic regions for AWCYCCGR] TAWNTCCGR 6 [Search intergenic regions for TAWNTCCGR]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	POX1 mRNA accumulation: decreased DCI1 mRNA accumulation: decreased FOX2 mRNA accumulation: decreased SPS19 mRNA accumulation: decreased SPS18 mRNA accumulation: decreased lipid particle morphology: abnormal peroxisomal morphology: abnormal resistance to capric acid: decreased utilization of carbon source: absent
unspecified	CTA1 mRNA accumulation: increased FOX3 mRNA accumulation: decreased
Large-scale survey
null	auxotrophy competitive fitness: increased resistance to hydrogen chloride: increased resistance to fluconazole: increased resistance to oleate: decreased resistance to camptothecin: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	52 total interaction(s) for 44 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Co-localization: 4 Reconstituted Complex: 3
Genetic Interactions	Negative Genetic: 20 Phenotypic Suppression: 1 Positive Genetic: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:48564 to 51707 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3144 48564..51707 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000048