OAF1/YAL051W Summary Help

Standard Name OAF1 1
Systematic Name YAL051W
Alias YAF1
Feature Type ORF, Verified
Description Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; involved in diauxic shift; OAF1 has a paralog, PIP2, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Oleate-Activated transcription Factor 1
Chromosomal Location
ChrI:48564 to 51707 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All OAF1 GO evidence and references
  View Computational GO annotations for OAF1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 18 genes
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
54 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-localization: 4
  • Reconstituted Complex: 3

Genetic Interactions
  • Negative Genetic: 20
  • Phenotypic Suppression: 1
  • Positive Genetic: 13

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,047
Molecular Weight (Da) 118,891
Isoelectric Point (pI) 6.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:48564 to 51707 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3144 48564..51707 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000048
References cited on this page View Complete Literature Guide for OAF1
1) Luo Y, et al.  (1996) Purification, identification, and properties of a Saccharomyces cerevisiae oleate-activated upstream activating sequence-binding protein that is involved in the activation of POX1. J Biol Chem 271(20):12068-75
2) Karpichev IV and Small GM  (1998) Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Mol Cell Biol 18(11):6560-70
3) Rottensteiner H, et al.  (1997) A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur J Biochem 247(3):776-83
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Zampar GG, et al.  (2013) Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast. Mol Syst Biol 9():651
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
7) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66