NVJ1/YHR195W Summary Help

Standard Name NVJ1 1
Systematic Name YHR195W
Alias VAB36
Feature Type ORF, Verified
Description Nuclear envelope protein; anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) (1, 2, 3)
Name Description Nucleus-Vacuole Junction 1
Chromosomal Location
ChrVIII:490747 to 491712 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NVJ1 GO evidence and references
  View Computational GO annotations for NVJ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
34 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Co-localization: 2
  • PCA: 6
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 9
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 321
Molecular Weight (Da) 36,421
Isoelectric Point (pI) 4.9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:490747 to 491712 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..966 490747..491712 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001238
References cited on this page View Complete Literature Guide for NVJ1
1) Pan X, et al.  (2000) Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Mol Biol Cell 11(7):2445-57
2) Roberts P, et al.  (2003) Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol Biol Cell 14(1):129-41
3) Millen JI, et al.  (2008) The luminal N-terminus of yeast Nvj1 is an inner nuclear membrane anchor. Traffic 9(10):1653-64