NUT2/YPR168W Summary

NUT2 BASIC INFORMATION

Standard Name	NUT2
Systematic Name	YPR168W
Alias	MED10
Feature Type	ORF, Verified
Description	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription (1)
Name Description	Negative regulation of URS Two 2

GO Annotations	All NUT2 GO evidence and references
	View Computational GO annotations for NUT2
Molecular Function
Manually curated	RNA polymerase II transcription mediator activity (IPI)
Biological Process
Manually curated	transcription from RNA polymerase II promoter (IDA, IPI)
Cellular Component
Manually curated	mediator complex (IDA)

Mutant Phenotype	All NUT2 Phenotype details and references
Large-scale survey
null	inviable

Interactions	NUT2 All interactions details and references
	91 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 56 Affinity Capture-Western: 12 Co-purification: 1 PCA: 1 Two-hybrid: 14
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 1 Synthetic Rescue: 4

Sequence Information

ChrXVI:878072 to 878545 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..474	878072..878545	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006372

NUT2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NUT2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NUT2]

1)	Gustafsson CM, et al. (1998) Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J Biol Chem 273(47):30851-4
2)	Tabtiang RK and Herskowitz I (1998) Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol Cell Biol 18(8):4707-18

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