Standard Name	NUC1
Systematic Name	YJL208C
Feature Type	ORF, Verified
Description	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy (1, 2, 3, 4, 5)
Name Description	NUClease 1

Chromosomal Location	ChrX:41183 to 40194 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NUC1
Molecular Function
Manually curated	endodeoxyribonuclease activity (IDA) exodeoxyribonuclease activity (IDA) ribonuclease activity (IDA)
Biological Process
Manually curated	apoptotic process (IMP) DNA catabolic process (IDA) DNA recombination (IMP) RNA catabolic process (IDA)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA) nucleus (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	apoptosis: decreased cell size: decreased growth in exponential phase: decreased rate metal resistance: decreased mutation frequency: decreased necrotic cell death: increased resistance to hypochlorous acid: decreased
overexpression	apoptosis: increased apoptosis: normal necrotic cell death: increased
Large-scale survey
null	auxotrophy chitin deposition: normal competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to glycolaldehyde: decreased resistance to trichothecene: increased stress resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	54 total interaction(s) for 43 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-Western: 2
Genetic Interactions	Negative Genetic: 23 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:41183 to 40194 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..990 41183..40194 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003744