NSR1/YGR159C Summary Help

Standard Name NSR1 1
Systematic Name YGR159C
Alias SHE5 2
Feature Type ORF, Verified
Description Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis (1, 3, 4)
Chromosomal Location
ChrVII:807656 to 806412 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NSR1 GO evidence and references
  View Computational GO annotations for NSR1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 13 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
overexpression
repressible
Resources
77 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 44
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 11
  • PCA: 4
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 414
Molecular Weight (Da) 44,535
Isoelectric Point (pI) 4.69
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:807656 to 806412 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1245 807656..806412 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003391
References cited on this page View Complete Literature Guide for NSR1
1) Lee WC, et al.  (1991) The NSR1 gene encodes a protein that specifically binds nuclear localization sequences and has two RNA recognition motifs. J Cell Biol 113(1):1-12
2) Espinet C, et al.  (1995) An efficient method to isolate yeast genes causing overexpression-mediated growth arrest. Yeast 11(1):25-32
3) Yan C and Melese T  (1993) Multiple regions of NSR1 are sufficient for accumulation of a fusion protein within the nucleolus. J Cell Biol 123(5):1081-91
4) Lee WC, et al.  (1992) NSR1 is required for pre-rRNA processing and for the proper maintenance of steady-state levels of ribosomal subunits. Mol Cell Biol 12(9):3865-71