Standard Name	NSR1 1 (see Nomenclature conflict Note)
Systematic Name	YGR159C
Alias	SHE5 2
Feature Type	ORF, Verified
Description	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis (1, 3, 4)

Chromosomal Location	ChrVII:807656 to 806412 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NSR1
Molecular Function
Manually curated	RNA binding (IDA) single-stranded DNA binding (IDA)
Biological Process
Manually curated	ribosomal small subunit assembly (TAS) rRNA processing (TAS)
Cellular Component
High-throughput	mitochondrion (IDA) nucleolus (IDA) nucleus (IDA)

Classical genetics
null	chronological lifespan: increased cold sensitivity: increased oxidative stress resistance: decreased Rpl7b-GFP distribution: abnormal vegetative growth: decreased rate viable
overexpression	fermentative metabolism: increased rate
reduction of function	box C/D snoRNA construct derived from U14 (snR128) localization: abnormal
Large-scale survey
null	budding pattern: abnormal cell cycle progression in G1 phase: increased duration cell shape: abnormal glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased haploproficient heat sensitivity: increased resistance to dimethyl sulfoxide: increased resistance to sodium arsenite: increased resistance to propan-1-ol: decreased resistance to doxorubicin: decreased stress resistance: increased telomere length: increased vegetative growth: decreased rate viable
overexpression	inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	75 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 42 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 11 PCA: 4 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 1 Synthetic Growth Defect: 7 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:807656 to 806412 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1245 807656..806412 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003391