NSE4/YDL105W Summary Help

Standard Name NSE4 1
Systematic Name YDL105W
Alias QRI2 2
Feature Type ORF, Verified
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair (1, 3, 4, 5)
Name Description Non-SMC Element 1
Chromosomal Location
ChrIV:272389 to 273597 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NSE4 GO evidence and references
  View Computational GO annotations for NSE4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
reduction of function
unspecified
Resources
30 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Co-purification: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Rescue: 3
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 402
Molecular Weight (Da) 46,121
Isoelectric Point (pI) 10.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:272389 to 273597 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1209 272389..273597 2004-02-11 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002263
References cited on this page View Complete Literature Guide for NSE4
1) Hu B, et al.  (2005) Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Mol Microbiol 55(6):1735-50
2) Simon M, et al.  (1994) Sequence of the PHO2-POL3 (CDC2) region of chromosome IV of Saccharomyces cerevisiae. Yeast 10(12):1653-6
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Zhao X and Blobel G  (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82
5) Bermudez-Lopez M, et al.  (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12