NRD1/YNL251C Summary Help

NRD1 BASIC INFORMATION

Standard Name NRD1 1
Systematic Name YNL251C
Feature Type ORF, Verified
Description RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; required for transcription termination and 3' end maturation of nonpolyadenylated RNAs (2, 3, 4)
Name Description Nuclear pre-mRNA Down-regulation 1
GO Annotations All NRD1 GO evidence and references
    View Computational GO annotations for NRD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All NRD1 Phenotype details and references
Classical genetics
conditional
null
repressible
Large-scale survey
null
reduction of function
Interactions NRD1 All interactions details and references
  View additional details at BioGRID
163 total interaction(s) for 128 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 58
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Co-localization: 1
  • Protein-peptide: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 4
Genetic Interactions
  • Negative Genetic: 74
  • Phenotypic Enhancement: 3
  • Positive Genetic: 10
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1
Sequence Information
ChrXIV:174316 to 172589 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1728 174316..172589 2005-11-07 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005195

NRD1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for NRD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NRD1]

1) Steinmetz EJ and Brow DA  (1996) Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1. Mol Cell Biol 16(12):6993-7003
2) Conrad NK, et al.  (2000) A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II. Genetics 154(2):557-71
3) Steinmetz EJ and Brow DA  (1998) Control of pre-mRNA accumulation by the essential yeast protein Nrd1 requires high-affinity transcript binding and a domain implicated in RNA polymerase II association. Proc Natl Acad Sci U S A 95(12):6699-704
4) Vasiljeva L, et al.  (2008) The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain. Nat Struct Mol Biol 15(8):795-804