Standard Name	NPR3 1
Systematic Name	YHL023C
Alias	RMD11 2
Feature Type	ORF, Verified
Description	Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair (1, 2, 3, 4, 5)
Name Description	Nitrogen Permease Regulator 1

Chromosomal Location	ChrVIII:62563 to 59123 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NPR3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular response to amino acid starvation (IMP) meiosis (IMP) regulation of TOR signaling cascade (IMP)
Cellular Component
Manually curated	extrinsic to fungal-type vacuolar membrane (IDA) Seh1-associated complex (IDA)

Classical genetics
null	tellurium atom accumulation: increased meiosis: abnormal meiosis: absent Gat1p distribution: abnormal resistance to hydroxyurea: decreased resistance to tellurite: increased sporulation efficiency: decreased utilization of nitrogen source: decreased
overexpression	cell cycle progression in G1 phase: abnormal
Large-scale survey
null	UV resistance: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased filamentous growth: decreased haploinsufficient invasive growth: absent metal resistance: decreased oxidative stress resistance: decreased resistance to 4-nitroquinoline N-oxide: decreased resistance to methyl methanesulfonate: decreased resistance to 1,4-dithiothreitol: decreased resistance to cycloheximide: decreased resistance to tunicamycin: decreased resistance to glycolaldehyde: decreased sporulation: absent sporulation efficiency: decreased starvation resistance: decreased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	113 total interaction(s) for 103 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 1 Affinity Capture-Western: 5
Genetic Interactions	Negative Genetic: 69 Phenotypic Enhancement: 2 Positive Genetic: 11 Synthetic Growth Defect: 7 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:62563 to 59123 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3441 62563..59123 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001015