NPL6/YMR091C Summary Help

Standard Name NPL6 1
Systematic Name YMR091C
Alias RSC7 2
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length (2, 3, 4, 5)
Name Description Nuclear Protein Localization 3, 6
Chromosomal Location
ChrXIII:451365 to 450058 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NPL6 GO evidence and references
  View Computational GO annotations for NPL6
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
228 total interaction(s) for 121 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 129
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Reconstituted Complex: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 74
  • Synthetic Lethality: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 435
Molecular Weight (Da) 49,650
Isoelectric Point (pI) 4.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:451365 to 450058 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1308 451365..450058 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004697
References cited on this page View Complete Literature Guide for NPL6
1) Bossie MA and Silver PA  (1992) Movement of macromolecules between the cytoplasm and the nucleus in yeast. Curr Opin Genet Dev 2(5):768-74
2) Wilson B, et al.  (2006) The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles. Genetics 172(2):795-809
3) Sadler I, et al.  (1989) A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. J Cell Biol 109(6 Pt 1):2665-75
4) Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19
5) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
6) Bossie MA, et al.  (1992) A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast. Mol Biol Cell 3(8):875-93