Standard Name	NOP8
Systematic Name	YOL144W
Feature Type	ORF, Verified
Description	Nucleolar protein required for 60S ribosomal subunit biogenesis (1)
Name Description	NucleOlar Protein

Chromosomal Location	ChrXV:53098 to 54552 | ORF Map | GBrowse

	View Computational GO annotations for NOP8
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ribosomal large subunit biogenesis (IMP)
Cellular Component
Manually curated	nucleolus (IDA)

Classical genetics
null	dessication resistance: increased inviable
repressible	mature 25S rRNA accumulation: decreased 60S ribosomal subunit accumulation: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal heat sensitivity: increased resistance to methyl methanesulfonate: decreased
null	cell size: increased heat sensitivity: increased inviable toxin resistance: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	45 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Co-fractionation: 2 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 5 Positive Genetic: 6 Synthetic Growth Defect: 1 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:53098 to 54552 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1455 53098..54552 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005504