NOP7/YGR103W Summary Help

Standard Name NOP7 1
Systematic Name YGR103W
Alias YPH1 2
Feature Type ORF, Verified
Description Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation (1, 3, 4, 5)
Name Description NucleOlar Protein 1
Chromosomal Location
ChrVII:695417 to 697234 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NOP7 GO evidence and references
  View Computational GO annotations for NOP7
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Large-scale survey
null
overexpression
repressible
Resources
389 total interaction(s) for 144 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 284
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 74
  • Co-purification: 5
  • PCA: 3
  • Reconstituted Complex: 5
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 4
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 605
Molecular Weight (Da) 69,877
Isoelectric Point (pI) 5.37
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:695417 to 697234 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1818 695417..697234 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003335
References cited on this page View Complete Literature Guide for NOP7
1) Harnpicharnchai P, et al.  (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15
2) Sakumoto N, et al.  (2001) Dual-specificity protein phosphatase Yvh1p, which is required for vegetative growth and sporulation, interacts with yeast pescadillo homolog in Saccharomyces cerevisiae. Biochem Biophys Res Commun 289(2):608-15
3) Oeffinger M, et al.  (2002) Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis. RNA 8(5):626-36
4) Du YC and Stillman B  (2002) Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell 109(7):835-48
5) Miles TD, et al.  (2005) Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Mol Cell Biol 25(23):10419-32