NOP4/YPL043W Summary Help

Standard Name NOP4 1
Systematic Name YPL043W
Alias NOP77
Feature Type ORF, Verified
Description Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) (1, 2, 3)
Name Description NucleOlar Protein 1
Chromosomal Location
ChrXVI:469939 to 471996 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NOP4 GO evidence and references
  View Computational GO annotations for NOP4
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
reduction of function
Resources
170 total interaction(s) for 93 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 143
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 4
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 11
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 685
Molecular Weight (Da) 77,825
Isoelectric Point (pI) 9.81
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:469939 to 471996 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2058 469939..471996 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005964
References cited on this page View Complete Literature Guide for NOP4
1) Sun C and Woolford JL Jr  (1994) The yeast NOP4 gene product is an essential nucleolar protein required for pre-rRNA processing and accumulation of 60S ribosomal subunits. EMBO J 13(13):3127-35
2) Sun C and Woolford JL Jr  (1997) The yeast nucleolar protein Nop4p contains four RNA recognition motifs necessary for ribosome biogenesis. J Biol Chem 272(40):25345-52
3) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27