Standard Name	NOG1
Systematic Name	YPL093W
Feature Type	ORF, Verified
Description	Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins (1, 2, 3)
Name Description	NucleOlar G-protein 1

Chromosomal Location	ChrXVI:370978 to 372921 | ORF Map | GBrowse

	View Computational GO annotations for NOG1
Molecular Function
Manually curated	GTP binding (ISS)
Biological Process
Manually curated	ribosomal large subunit biogenesis (IDA, IMP) ribosomal subunit export from nucleus (IMP, IPI) rRNA processing (IMP)
Cellular Component
Manually curated	nucleolus (IDA) preribosome, large subunit precursor (IDA)
High-throughput	preribosome, large subunit precursor (IDA)

Classical genetics
null	inviable
reduction of function	vegetative growth: decreased
unspecified	vegetative growth: decreased vegetative growth: normal
Large-scale survey
conditional	resistance to methyl methanesulfonate: decreased
null	cell size: decreased competitive fitness: decreased haploinsufficient inviable starvation resistance: decreased
overexpression	resistance to sirolimus: increased vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	302 total interaction(s) for 144 unique genes/features.
Physical Interactions	Affinity Capture-MS: 249 Affinity Capture-RNA: 1 Affinity Capture-Western: 31 Co-fractionation: 2 Co-purification: 3 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 6 Positive Genetic: 1 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:370978 to 372921 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1944 370978..372921 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006014