Standard Name	NNK1 1
Systematic Name	YKL171W
Feature Type	ORF, Verified
Description	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm (1, 2, 3, 4, 5)
Name Description	Nitrogen Network Kinase 1

Chromosomal Location	ChrXI:127475 to 130261 | ORF Map | GBrowse

	View Computational GO annotations for NNK1
Molecular Function
Manually curated	protein kinase activity (ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	proteolysis (IPI)
High-throughput	protein phosphorylation (IDA)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal cell size: increased
Large-scale survey
null	competitive fitness: decreased vacuolar morphology: abnormal vegetative growth: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	120 total interaction(s) for 107 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 2 Affinity Capture-Western: 5 Biochemical Activity: 43 PCA: 1 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 4 Negative Genetic: 36 Positive Genetic: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:127475 to 130261 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2787 127475..130261 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001654