NMT1/YLR195C Summary Help

Standard Name NMT1 1
Systematic Name YLR195C
Alias CDC72 2
Feature Type ORF, Verified
Description N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction (1, 3, 4, 5)
Name Description N-Myristoyl Transferase 5
Chromosomal Location
ChrXII:543304 to 541937 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 142 cM
Gene Ontology Annotations All NMT1 GO evidence and references
  View Computational GO annotations for NMT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
reduction of function
unspecified
Resources
50 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 16
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 455
Molecular Weight (Da) 52,837
Isoelectric Point (pI) 7.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:543304 to 541937 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 142 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1368 543304..541937 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004185
References cited on this page View Complete Literature Guide for NMT1
1) Duronio RJ, et al.  (1989) Disruption of the yeast N-myristoyl transferase gene causes recessive lethality. Science 243(4892):796-800
2) Reed SI, et al.  (1988) Isolation and characterization of two genes encoding yeast mating pheromone signaling elements: CDC72 and CDC73. Cold Spring Harb Symp Quant Biol 53 Pt 2:621-7
3) Knoll LJ, et al.  (1992) Analysis of the compartmentalization of myristoyl-CoA:protein N-myristoyltransferase in Saccharomyces cerevisiae. J Biol Chem 267(8):5366-73
4) Stone DE, et al.  (1991) N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase. Genes Dev 5(11):1969-81
5) Towler DA, et al.  (1987) Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase. J Biol Chem 262(3):1030-6