NMD3/YHR170W Summary

NMD3 BASIC INFORMATION

Standard Name	NMD3
Systematic Name	YHR170W
Alias	SRC5
Feature Type	ORF, Verified
Description	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex (1, 2)

GO Annotations	All NMD3 GO evidence and references
	View Computational GO annotations for NMD3
Molecular Function
Manually curated	protein binding (ISS) ribosomal large subunit binding (IDA) RNA binding (ISS)
Biological Process
Manually curated	ribosomal large subunit assembly (IMP) ribosomal large subunit export from nucleus (IMP)
Cellular Component
Manually curated	cytosol (IDA) cytosolic large ribosomal subunit (IDA)

Mutant Phenotype	All NMD3 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable

Interactions	NMD3 All interactions details and references
	93 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 36 Affinity Capture-Western: 29 Co-fractionation: 1 Co-purification: 4 PCA: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 7 Synthetic Lethality: 7 Synthetic Rescue: 4

Sequence Information

ChrVIII:443829 to 445385 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1557	443829..445385	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001213

NMD3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NMD3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NMD3]

1)	Ho JH and Johnson AW (1999) NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2389-99
2)	Ho JH, et al. (2000) Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J Cell Biol 151(5):1057-66

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