NMD2/YHR077C Summary Help

NMD2 BASIC INFORMATION

Standard Name NMD2 1
Systematic Name YHR077C
Alias IFS1 , SUA1 2 , UPF2 3 , SUP111 4
Feature Type ORF, Verified
Description Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance (1, 3, 5, 6)
Name Description Nonsense-mediated MRNA Decay 1
GO Annotations All NMD2 GO evidence and references
    View Computational GO annotations for NMD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All NMD2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions NMD2 All interactions details and references
71 total interaction(s) for 52 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-Western: 6
  • Reconstituted Complex: 1
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 22
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 7
Sequence Information
ChrVIII:255758 to 252376 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 51 cM
Last Update Coordinates: 2005-11-07 | Sequence: 1999-11-17
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..6 255758..255753 2005-11-07 1999-11-17
Intron 7..119 255752..255640 2005-11-07 1999-11-17
CDS 120..3383 255639..252376 2005-11-07 1999-11-17
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001119

NMD2 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NMD2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NMD2]

1) He F and Jacobson A  (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54
2) Hampsey M, et al.  (1991) Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae. Biochimie 73(12):1445-55
3) Cui Y, et al.  (1995) Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev 9(4):423-36
4) Ono B, et al.  (2005) Suppression of termination mutations caused by defects of the NMD machinery in Saccharomyces cerevisiae. Genes Genet Syst 80(5):311-6
5) He F, et al.  (1997) Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol Cell Biol 17(3):1580-94
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63