NMD2/YHR077C Summary Help

Standard Name NMD2 1
Systematic Name YHR077C
Alias IFS1 , SUA1 2 , UPF2 3 , SUP111 4
Feature Type ORF, Verified
Description Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance (1, 3, 5, 6)
Name Description Nonsense-mediated MRNA Decay 1
Chromosomal Location
ChrVIII:255756 to 252374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 51 cM
Gene Ontology Annotations All NMD2 GO evidence and references
  View Computational GO annotations for NMD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
209 total interaction(s) for 160 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Reconstituted Complex: 1
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 100
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 45
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 3
  • Synthetic Rescue: 12

Expression Summary
Length (a.a.) 1,089
Molecular Weight (Da) 126,746
Isoelectric Point (pI) 4.83
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:255756 to 252374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 51 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1999-11-17
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..6 255756..255751 2011-02-03 1999-11-17
Intron 7..119 255750..255638 2011-02-03 1999-11-17
CDS 120..3383 255637..252374 2011-02-03 1999-11-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001119
References cited on this page View Complete Literature Guide for NMD2
1) He F and Jacobson A  (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54
2) Hampsey M, et al.  (1991) Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae. Biochimie 73(12):1445-55
3) Cui Y, et al.  (1995) Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev 9(4):423-36
4) Ono B, et al.  (2005) Suppression of termination mutations caused by defects of the NMD machinery in Saccharomyces cerevisiae. Genes Genet Syst 80(5):311-6
5) He F, et al.  (1997) Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol Cell Biol 17(3):1580-94
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63