NKP2/YLR315W Summary Help

Standard Name NKP2 1
Systematic Name YLR315W
Feature Type ORF, Verified
Description Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 (1, 2, 3)
Name Description Non-essential Kinetochore Protein 1
Chromosomal Location
ChrXII:764808 to 765269 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NKP2 GO evidence and references
  View Computational GO annotations for NKP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 60 genes
Resources
Large-scale survey
null
Resources
157 total interaction(s) for 119 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-Western: 1
  • Co-crystal Structure: 1
  • PCA: 5
  • Reconstituted Complex: 1
  • Two-hybrid: 51

Genetic Interactions
  • Negative Genetic: 48
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 5
  • Positive Genetic: 3
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 153
Molecular Weight (Da) 17,862
Isoelectric Point (pI) 4.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:764808 to 765269 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..462 764808..765269 2004-02-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004307
References cited on this page View Complete Literature Guide for NKP2
1) Cheeseman IM, et al.  (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72
2) Fernius J and Marston AL  (2009) Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3. PLoS Genet 5(9):e1000629
3) Schleiffer A, et al.  (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13