NIP100/YPL174C Summary Help

Standard Name NIP100 1
Systematic Name YPL174C
Alias PAC13 2
Feature Type ORF, Verified
Description Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) (1, 3)
Name Description Nuclear ImPort
Chromosomal Location
ChrXVI:222773 to 220167 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NIP100 GO evidence and references
  View Computational GO annotations for NIP100
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
repressible
Resources
452 total interaction(s) for 280 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 18
  • Co-fractionation: 1
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 122

Genetic Interactions
  • Negative Genetic: 189
  • Phenotypic Enhancement: 2
  • Positive Genetic: 24
  • Synthetic Growth Defect: 50
  • Synthetic Lethality: 38

Resources
Expression Summary
histogram
Resources
Length (a.a.) 868
Molecular Weight (Da) 100,289
Isoelectric Point (pI) 5.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:222773 to 220167 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2607 222773..220167 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006095
References cited on this page View Complete Literature Guide for NIP100
1) Kahana JA, et al.  (1998) The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B. Mol Biol Cell 9(7):1741-56
2) Geiser JR, et al.  (1997) Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol Biol Cell 8(6):1035-50
3) Fujiwara T, et al.  (1999) Bni1p regulates microtubule-dependent nuclear migration through the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8016-27