NHP6B/YBR089C-A Summary

NHP6B BASIC INFORMATION

Standard Name	NHP6B
Systematic Name	YBR089C-A
Alias	YBR090C-A
Feature Type	ORF, Verified
Description	High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters (1)
Name Description	Non-Histone Protein 2

GO Annotations	All NHP6B GO evidence and references
	View Computational GO annotations for NHP6B
Molecular Function
Manually curated	chromatin binding (IDA, ISS)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	chromatin organization (ISS) chromatin remodeling (IMP) nucleosome assembly (IDA) positive regulation of transcription from RNA polymerase II promoter (IMP, IPI) regulation of transcription from RNA polymerase II promoter (ISS) regulation of transcription from RNA polymerase III promoter (IDA, IGI, IMP)
Cellular Component
Manually curated	nuclear chromatin (ISS)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 311 )

Mutant Phenotype	All NHP6B Phenotype details and references
Classical genetics
overexpression	NHP6A mRNA accumulation: decreased
Large-scale survey
null	competitive fitness: decreased toxin resistance: increased
overexpression	inviable vegetative growth: decreased

Interactions	NHP6B All interactions details and references
	98 total interaction(s) for 69 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Co-localization: 1 Co-purification: 1 Reconstituted Complex: 17 Two-hybrid: 31
Genetic Interactions	Dosage Rescue: 6 Phenotypic Enhancement: 12 Phenotypic Suppression: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 6 Synthetic Rescue: 1

Sequence Information

ChrII:426483 to 426184 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
5' UTR intron	-384..-28	426867..426511	2007-04-04	2007-04-04
CDS	1..300	426483..426184	2004-07-16	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002157

NHP6B RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NHP6B

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NHP6B]

1)	Fragiadakis GS, et al. (2004) Nhp6 facilitates Aft1 binding and Ssn6 recruitment, both essential for FRE2 transcriptional activation. EMBO J 23(2):333-42
2)	Kolodrubetz D, et al. (1988) Amino-terminal sequence of a Saccharomyces cerevisiae nuclear protein, NHP6, shows significant identity to bovine HMG1. FEBS Lett 238(1):175-9

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