Standard Name	NHP2 1
Systematic Name	YDL208W
Feature Type	ORF, Verified
Description	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing (1, 2)
Name Description	Non-Histone Protein 1

Chromosomal Location	ChrIV:87512 to 87982 | ORF Map | GBrowse

	View Computational GO annotations for NHP2
Molecular Function
Manually curated	snoRNA binding (IDA)
Biological Process
Manually curated	cleavage involved in rRNA processing (IMP) rRNA pseudouridine synthesis (IMP) snRNA pseudouridine synthesis (IDA, IMP)
Cellular Component
Manually curated	box H/ACA snoRNP complex (IPI)

Classical genetics
null	inviable
repressible	pre-rRNA modification: decreased vegetative growth: decreased rate
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
reduction of function	competitive fitness: decreased telomere length: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	103 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 60 Affinity Capture-RNA: 6 Affinity Capture-Western: 10 Co-purification: 1 PCA: 8 Reconstituted Complex: 7 Two-hybrid: 5
Genetic Interactions	Synthetic Growth Defect: 2 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:87512 to 87982 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2005-11-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..471 87512..87982 2011-02-03 2005-11-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002367