Standard Name	NDT80 1
Systematic Name	YHR124W
Feature Type	ORF, Verified
Description	Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) (1, 2, 3)
Name Description	Non-DiTyrosine 1

Chromosomal Location	ChrVIII:356561 to 358444 | ORF Map | GBrowse

	View Computational GO annotations for NDT80
Molecular Function
Manually curated	sequence-specific DNA binding transcription factor activity (IDA, IMP, IPI)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	meiosis (IEP, IGI, IMP) transcription, DNA-dependent (IGI, IMP, IPI)
Cellular Component
Manually curated	nuclear chromosome (IDA)

Binding motifs	GMCACAAAA 4 [Search intergenic regions for GMCACAAAA]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	CLB1 mRNA accumulation: decreased meiosis: arrested meiotic recombination: abnormal Zip1p accumulation: increased Red1p accumulation: increased sporulation: decreased sporulation: absent viable
unspecified	IME2 mRNA accumulation: delayed SPS4 mRNA accumulation: decreased sporulation: absent
Large-scale survey
null	competitive fitness: decreased haploproficient hyperosmotic stress resistance: decreased metal resistance: decreased sporulation: absent sporulation efficiency: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	54 total interaction(s) for 46 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Biochemical Activity: 4
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 14 Phenotypic Enhancement: 11 Phenotypic Suppression: 7 Positive Genetic: 5 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:356561 to 358444 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1884 356561..358444 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001166