Standard Name	NDE1 1
Systematic Name	YMR145C
Alias	NDH1
Feature Type	ORF, Verified
Description	Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	NADH Dehydrogenase, External 1

Chromosomal Location	ChrXIII:556475 to 554793 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NDE1
Molecular Function
Manually curated	NADH dehydrogenase activity (IDA, ISS)
Biological Process
Manually curated	chronological cell aging (IMP) glucose catabolic process to ethanol (IMP) NADH oxidation (IDA)
Cellular Component
Manually curated	mitochondrion (IDA, IMP)
High-throughput	mitochondrion (IDA)

Classical genetics
null	lifespan: increased resistance to artemisinin: increased respiratory growth: decreased rate
overexpression	reactive oxygen species accumulation: increased resistance to artemisinin: decreased
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased filamentous growth: decreased invasive growth: absent resistance to oleate: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to arsenite(3-): decreased resistance to caffeine: decreased resistance to fluconazole: decreased resistance to sulfometuron methyl: decreased resistance to quinine: decreased resistance to L-canavanine: increased resistance to ethanol: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	59 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Negative Genetic: 19 Phenotypic Enhancement: 2 Phenotypic Suppression: 4 Positive Genetic: 10 Synthetic Growth Defect: 2 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:556475 to 554793 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1683 556475..554793 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004753