NCR1/YPL006W Summary Help

Standard Name NCR1 1
Systematic Name YPL006W
Feature Type ORF, Verified
Description Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p (1, 2, 3)
Name Description Niemann-pick type C Related 1
Chromosomal Location
ChrXVI:544631 to 548143 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NCR1 GO evidence and references
  View Computational GO annotations for NCR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
gain of function
null
Large-scale survey
null
overexpression
Resources
102 total interaction(s) for 97 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 4
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 79
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 7
  • Synthetic Growth Defect: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,170
Molecular Weight (Da) 132,644
Isoelectric Point (pI) 4.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:544631 to 548143 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3513 544631..548143 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000005927
References cited on this page View Complete Literature Guide for NCR1
1) Zhang S, et al.  (2004) Ncr1p, the yeast ortholog of mammalian Niemann Pick C1 protein, is dispensable for endocytic transport. Traffic 5(12):1017-30
2) Malathi K, et al.  (2004) Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. J Cell Biol 164(4):547-56
3) Vilaca R, et al.  (2014) Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol 91(3):438-51