Standard Name	NAS2 1
Systematic Name	YIL007C
Feature Type	ORF, Verified
Description	Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description	Non-ATPase Subunit 1

Chromosomal Location	ChrIX:343656 to 342994 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	proteasome regulatory particle assembly (IDA, IGI, IMP) ubiquitin-dependent protein catabolic process (ISS)
Cellular Component
Manually curated	cytoplasm (IDA) cytosol (IDA) nucleus (IDA)

Large-scale survey
null	competitive fitness: increased resistance to sirolimus: decreased resistance to wortmannin: decreased resistance to cycloheximide: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	60 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 15 Biochemical Activity: 1 Reconstituted Complex: 1 Two-hybrid: 17
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 6 Phenotypic Enhancement: 6 Phenotypic Suppression: 1 Synthetic Growth Defect: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:343656 to 342994 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..663 343656..342994 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001269