Standard Name	NAM8
Systematic Name	YHR086W
Alias	MRE2 , MUD15
Feature Type	ORF, Verified
Description	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function (1, 2, 3, 4)
Name Description	Nuclear Accommodation of Mitochondria

Chromosomal Location	ChrVIII:278153 to 279724 | ORF Map | GBrowse

	View Computational GO annotations for NAM8
Molecular Function
Manually curated	mRNA binding (IPI) RNA binding (IPI)
Biological Process
Manually curated	mRNA splice site selection (IMP) mRNA splicing, via spliceosome (IPI) positive regulation of mRNA splicing, via spliceosome (IMP)
Cellular Component
Manually curated	commitment complex (IPI) U1 snRNP (IDA) U2-type prespliceosome (IDA)

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient hyperosmotic stress resistance: decreased resistance to ethanol: decreased sporulation: decreased sporulation efficiency: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	214 total interaction(s) for 96 unique genes/features.
Physical Interactions	Affinity Capture-MS: 148 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Co-purification: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 31 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 8 Synthetic Growth Defect: 4 Synthetic Lethality: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:278153 to 279724 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1572 278153..279724 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001128