NAM7/YMR080C Summary Help

NAM7 BASIC INFORMATION

Standard Name NAM7
Systematic Name YMR080C
Alias IFS2 , MOF4 , UPF1 1 , SUP113 2
Feature Type ORF, Verified
Description ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance (3, 4, 5, 6)
Name Description Nuclear Accommodation of Mitochondria
GO Annotations All NAM7 GO evidence and references
    View Computational GO annotations for NAM7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All NAM7 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Interactions NAM7 All interactions details and references
121 total interaction(s) for 86 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 14
  • PCA: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 5
  • Two-hybrid: 18
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 15
  • Phenotypic Suppression: 28
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 3
  • Synthetic Rescue: 9
Sequence Information
ChrXIII:429626 to 426711 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 60 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2916 429626..426711 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004685

NAM7 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NAM7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NAM7]

1) Leeds P, et al.  (1991) The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev 5(12A):2303-14
2) Ono B, et al.  (2005) Suppression of termination mutations caused by defects of the NMD machinery in Saccharomyces cerevisiae. Genes Genet Syst 80(5):311-6
3) de la Cruz J, et al.  (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8
4) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
5) Sheth U and Parker R  (2006) Targeting of aberrant mRNAs to cytoplasmic processing bodies. Cell 125(6):1095-109
6) Takahashi S, et al.  (2008) Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA 14(9):1950-8