Standard Name	NAB3 1
Systematic Name	YPL190C
Alias	HMD1
Feature Type	ORF, Verified
Description	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing (1, 2, 3, 4)
Name Description	Nuclear polyAdenylated RNA-Binding 1

Chromosomal Location	ChrXVI:187725 to 185317 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NAB3
Molecular Function
Manually curated	RNA binding (IDA) transcription regulatory region RNA binding (IDA)
Biological Process
Manually curated	antisense RNA transcript catabolic process (IMP) CUT catabolic process (IMP) mRNA 3'-end processing (IMP) nuclear mRNA surveillance (IMP) snoRNA 3'-end processing (IMP) snRNA 3'-end processing (IMP) termination of RNA polymerase II transcription, exosome-dependent (IDA) tRNA 3'-end processing (IMP)
Cellular Component
Manually curated	Nrd1 complex (IDA) nucleus (IDA)

Classical genetics
conditional	cryptic unstable transcripts (CUTs) accumulation: increased cell cycle progression through the G2/M phase transition: decreased resistance to camptothecin: decreased silencing: decreased
null	inviable
repressible	NEL025c mRNA accumulation: abnormal
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal redox state: abnormal
null	inviable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	114 total interaction(s) for 77 unique genes/features.
Physical Interactions	Affinity Capture-MS: 44 Affinity Capture-RNA: 40 Affinity Capture-Western: 6 Biochemical Activity: 5 PCA: 3 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 3 Phenotypic Enhancement: 2 Synthetic Growth Defect: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:187725 to 185317 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2409 187725..185317 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006111