MGM1/YOR211C Summary Help

Standard Name MGM1
Systematic Name YOR211C
Alias MNA1
Feature Type ORF, Verified
Description Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy (1, 2, 3, 4, 5, 6, 7)
Name Description Mitochondrial Genome Maintenance
Chromosomal Location
ChrXV:741569 to 738924 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 123 cM
Gene Ontology Annotations All MGM1 GO evidence and references
  View Computational GO annotations for MGM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 48 genes
Classical genetics
reduction of function
Large-scale survey
113 total interaction(s) for 91 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-Western: 7
  • Biochemical Activity: 2
  • Co-fractionation: 2
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 78
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 881
Molecular Weight (Da) 99,177
Isoelectric Point (pI) 7.61
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:741569 to 738924 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 123 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2006-10-03
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2646 741569..738924 2011-02-03 2006-10-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005737
References cited on this page View Complete Literature Guide for MGM1
1) Wong ED, et al.  (2000) The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J Cell Biol 151(2):341-52
2) Olichon A, et al.  (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6
3) Sesaki H, et al.  (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56
4) Amutha B, et al.  (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23
5) Sesaki H and Jensen RE  (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303
6) Zick M, et al.  (2009) Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion. FEBS Lett 583(13):2237-43
7) Chan EY and McQuibban GA  (2012) Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1). J Biol Chem 287(48):40131-9