Standard Name	MXR2 1
Systematic Name	YCL033C
Feature Type	ORF, Verified
Description	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan (1, 2, 3, 4) Also known as: MSRB
Name Description	peptide Methionine sulfoXide Reductase 5

Chromosomal Location	ChrIII:63282 to 62776 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MXR2
Molecular Function
Manually curated	peptide-methionine (R)-S-oxide reductase activity (IDA, IMP)
Biological Process
Manually curated	cellular response to oxidative stress (IGI, IMP)
Cellular Component
Manually curated	mitochondrion (IDA)

Classical genetics
null	reactive oxygen species accumulation: increased oxidative stress resistance: decreased Cyc1p accumulation: decreased replicative lifespan: normal replicative lifespan: increased resistance to L-methionine (R)-S-oxide: decreased resistance to L-methionine (S)-S-oxide: decreased resistance to hydrogen peroxide: decreased respiratory growth: decreased rate viable
overexpression	oxidative stress resistance: increased replicative lifespan: increased replicative lifespan: normal
Large-scale survey
null	auxotrophy competitive fitness: increased metal resistance: decreased resistance to arsenite(3-): decreased resistance to nickel sulfate: decreased resistance to quinine: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	16 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 4 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 4 Phenotypic Enhancement: 1 Positive Genetic: 3 Synthetic Growth Defect: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:63282 to 62776 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2000-09-13 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..507 63282..62776 2000-09-13 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000538