MXR1/YER042W Summary Help

MXR1 BASIC INFORMATION

Standard Name MXR1 1
Systematic Name YER042W
Feature Type ORF, Verified
Description Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan (2, 3, 4, 5, 6, 7)
Also known as: MSRA
Name Description peptide Methionine sulfoXide Reductase 1
GO Annotations All MXR1 GO evidence and references
    View Computational GO annotations for MXR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All MXR1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions MXR1 All interactions details and references
10 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 2
  • Two-hybrid: 2
Genetic Interactions
  • Synthetic Growth Defect: 2
Sequence Information
ChrV:234936 to 235490 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..555 234936..235490 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000844

MXR1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MXR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MXR1]

1) Hansen J  (1999) Inactivation of MXR1 abolishes formation of dimethyl sulfide from dimethyl sulfoxide in Saccharomyces cerevisiae. Appl Environ Microbiol 65(9):3915-9
2) Moskovitz J, et al.  (1997) The yeast peptide-methionine sulfoxide reductase functions as an antioxidant in vivo. Proc Natl Acad Sci U S A 94(18):9585-9
3) Moskovitz J, et al.  (1998) Overexpression of peptide-methionine sulfoxide reductase in Saccharomyces cerevisiae and human T cells provides them with high resistance to oxidative stress. Proc Natl Acad Sci U S A 95(24):14071-5
4) Kryukov GV, et al.  (2002) Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A 99(7):4245-50
5) Koc A, et al.  (2004) Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A 101(21):7999-8004
6) Le DT, et al.  (2009) Functional Analysis of Free Methionine-R-sulfoxide Reductase from Saccharomyces cerevisiae. J Biol Chem 284(7):4354-64
7) Sideri TC, et al.  (2009) Methionine sulphoxide reductases protect iron-sulphur clusters from oxidative inactivation in yeast. Microbiology 155(Pt 2):612-23