SUMMARY PARAGRAPH for MVD1
MVD1 encodes diphosphomevalonate decarboxylase, which converts mevalonate-5-pyrophosphate to isopentenyl pyrophosphate in the biosynthesis of isoprenoids and sterols, including ergosterol in yeast (2, 5, 6). MVD1 is essential for viability; a temperature-sensitive mvd1 mutation is auxotrophic for ergosterol and lacks diphosphomevalonate decarboxylase activity (2, 4). Mvd1p acts as a homodimer; the temperature-sensitive erg19-34 allele impairs dimerization (3).
Mvd1p is a member of the GHMP kinase superfamily, which includes small-molecule kinases such as galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (7, 8). The human diphosphomevalonate decarboxylase has been cloned and sequenced, and is a possible target in the treatment of hypercholesterolemia (5). The Arabidopsis enzyme, encoded by AtMVD1, complements S. cerevisiae mvd1 mutant phenotypes (9).
Last updated: 2009-07-29