Standard Name	MUP1
Systematic Name	YGR055W
Feature Type	ORF, Verified
Description	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake (1, 2)
Name Description	Methionine UPtake

Chromosomal Location	ChrVII:599417 to 601141 | ORF Map | GBrowse

	View Computational GO annotations for MUP1
Molecular Function
Manually curated	L-methionine secondary active transmembrane transporter activity (IDA)
Biological Process
Manually curated	cysteine transport (IDA) methionine transport (IDA) sulfur amino acid transport (IMP)
Cellular Component
Manually curated	integral to plasma membrane (ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	tellurium atom accumulation: increased resistance to tellurite: decreased toxin resistance: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased haploproficient resistance to hydroxyurea: decreased resistance to benzo[a]pyrene: decreased resistance to benzo[a]pyrene: increased resistance to selenomethionine: increased resistance to sodium selenide: decreased resistance to quinine: decreased resistance to propolis extract: decreased resistance to CTBT: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased starvation resistance: decreased toxin resistance: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	125 total interaction(s) for 112 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 PCA: 54 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 50 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Growth Defect: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:599417 to 601141 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1725 599417..601141 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000003287