FLO11/YIR019C Summary Help

Standard Name FLO11 1
Systematic Name YIR019C
Alias STA4 , MUC1 2
Feature Type ORF, Verified
Description GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain; a portion is cleaved and shed from cells, and free extracellular Flo11p contributes to the surface properties of cells (2, 3, 4, 5, 6, 7)
Name Description FLOcculation
Chromosomal Location
ChrIX:393675 to 389572 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All FLO11 GO evidence and references
  View Computational GO annotations for FLO11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 1 genes
Regulators 100 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
Resources
86 total interaction(s) for 78 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 22
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 51
  • Positive Genetic: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,367
Molecular Weight (Da) 136,109
Isoelectric Point (pI) 4.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:393675 to 389572 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4104 393675..389572 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001458
References cited on this page View Complete Literature Guide for FLO11
1) Lo WS and Dranginis AM  (1996) FLO11, a yeast gene related to the STA genes, encodes a novel cell surface flocculin. J Bacteriol 178(24):7144-51
2) Lambrechts MG, et al.  (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 93(16):8419-24
3) Rupp S, et al.  (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69
4) Guo B, et al.  (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc Natl Acad Sci U S A 97(22):12158-63
5) Douglas LM, et al.  (2007) Expression and Characterization of the Flocculin Flo11/Muc1, a Saccharomyces cerevisiae Mannoprotein with Homotypic Properties of Adhesion. Eukaryot Cell 6(12):2214-21
6) Karunanithi S, et al.  (2010) Shedding of the Mucin-Like Flocculin Flo11p Reveals a New Aspect of Fungal Adhesion Regulation. Curr Biol 20(15):1389-1395
7) Vachova L, et al.  (2011) Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies. J Cell Biol 194(5):679-87