MTF2/YDL044C Summary Help

Standard Name MTF2 1
Systematic Name YDL044C
Alias NAM1
Feature Type ORF, Verified
Description Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription (2, 3, 4)
Name Description Mitochondrial Transcription Factor 1, 5
Chromosomal Location
ChrIV:375289 to 373967 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -17.93 cM
Gene Ontology Annotations All MTF2 GO evidence and references
  View Computational GO annotations for MTF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
Resources
24 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 5
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 440
Molecular Weight (Da) 51,192
Isoelectric Point (pI) 6.72
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:375289 to 373967 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -17.93 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1323 375289..373967 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002202
References cited on this page View Complete Literature Guide for MTF2
1) Lisowsky T and Michaelis G  (1989) Mutations in the genes for mitochondrial RNA polymerase and a second mitochondrial transcription factor of Saccharomyces cerevisiae. Mol Gen Genet 219(1-2):125-8
2) Wallis MG, et al.  (1994) The NAM1 protein (NAM1p), which is selectively required for cox1, cytb and atp6 transcript processing/stabilisation, is located in the yeast mitochondrial matrix. Eur J Biochem 222(1):27-32
3) Asher EB, et al.  (1989) Novel class of nuclear genes involved in both mRNA splicing and protein synthesis in Saccharomyces cerevisiae mitochondria. Mol Gen Genet 215(3):517-28
4) Rodeheffer MS, et al.  (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22
5) Lisowsky T  (1990) Molecular analysis of the mitochondrial transcription factor mtf2 of Saccharomyces cerevisiae. Mol Gen Genet 220(2):186-90