Standard Name	MTF1
Systematic Name	YMR228W
Feature Type	ORF, Verified
Description	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation (1, 2, 3, 4, 5)
Name Description	Mitochondrial Transcription Factor 6

Chromosomal Location	ChrXIII:724626 to 725651 | ORF Map | GBrowse
	Genetic position: 157.9 cM

	View Computational GO annotations for MTF1
Molecular Function
Manually curated	mitochondrial RNA polymerase binding promoter specificity activity (IDA, IPI)
Biological Process
Manually curated	transcription initiation from mitochondrial promoter (IDA)
Cellular Component
Manually curated	mitochondrial DNA-directed RNA polymerase complex (IDA) mitochondrial intermembrane space (IDA) mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	mitochondrial genome maintenance: abnormal
Large-scale survey
null	UV resistance: decreased glutathione excretion: increased competitive fitness: decreased haploinsufficient heat sensitivity: increased mitochondrial genome maintenance: abnormal mitochondrial morphology: abnormal resistance to quinine: increased resistance to citric acid: decreased resistance to ethanol: decreased resistance to quinine: decreased resistance to sorbate: decreased resistance to benzo[a]pyrene: decreased respiratory growth: absent respiratory growth: decreased rate stress resistance: increased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	30 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 2 Biochemical Activity: 1 Co-purification: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 1 Synthetic Growth Defect: 6 Synthetic Lethality: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:724626 to 725651 | ORF Map | GBrowse
	Genetic position: 157.9 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1026 724626..725651 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004841