MSS1/YMR023C Summary Help

Standard Name MSS1
Systematic Name YMR023C
Alias PET53
Feature Type ORF, Verified
Description Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 (1, 2, 3, 4)
Name Description Mitochondrial Splicing System
Chromosomal Location
ChrXIII:321017 to 319437 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MSS1 GO evidence and references
  View Computational GO annotations for MSS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
204 total interaction(s) for 154 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 169
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 4
  • Positive Genetic: 21
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 526
Molecular Weight (Da) 58,351
Isoelectric Point (pI) 7.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:321017 to 319437 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1581 321017..319437 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004625
References cited on this page View Complete Literature Guide for MSS1
1) Decoster E, et al.  (1993) MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. J Mol Biol 232(1):79-88
2) Colby G, et al.  (1998) MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. J Biol Chem 273(43):27945-52
3) Li X and Guan MX  (2002) A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation. Mol Cell Biol 22(21):7701-11
4) Umeda N, et al.  (2005) Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J Biol Chem 280(2):1613-24