MSO1/YNR049C Summary Help

Standard Name MSO1 1
Systematic Name YNR049C
Feature Type ORF, Verified
Description Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress (1, 2, 3, 4)
Name Description Multicopy suppressor of Sec One 1
Chromosomal Location
ChrXIV:713655 to 713023 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MSO1 GO evidence and references
  View Computational GO annotations for MSO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
109 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 22
  • PCA: 8
  • Reconstituted Complex: 4
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 4
  • Negative Genetic: 42
  • Positive Genetic: 2
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 10
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 210
Molecular Weight (Da) 23,351
Isoelectric Point (pI) 10.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:713655 to 713023 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..633 713655..713023 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005332
References cited on this page View Complete Literature Guide for MSO1
1) Aalto MK, et al.  (1997) Mso1p: a yeast protein that functions in secretion and interacts physically and genetically with Sec1p. Proc Natl Acad Sci U S A 94(14):7331-6
2) Jantti J, et al.  (2002) Characterization of temperature-sensitive mutations in the yeast syntaxin 1 homologues Sso1p and Sso2p, and evidence of a distinct function for Sso1p in sporulation. J Cell Sci 115(Pt 2):409-20
3) Knop M, et al.  (2005) Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast. Mol Biol Cell 16(10):4543-56
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76