MSN1/YOL116W Summary Help

Standard Name MSN1 1
Systematic Name YOL116W
Alias FUP1 2 , HRB382 , MSS10 3 , 4 , PHD2 5
Feature Type ORF, Verified
Description Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress (1, 2, 4, 6, 7, 8)
Name Description Multicopy suppressor of SNF1 mutation 1
Chromosomal Location
ChrXV:99809 to 100957 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MSN1 GO evidence and references
  View Computational GO annotations for MSN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 304 genes
Regulators 97 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
90 total interaction(s) for 84 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 12
  • Negative Genetic: 60
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Haploinsufficiency: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 382
Molecular Weight (Da) 43,060
Isoelectric Point (pI) 6.69
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:99809 to 100957 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1149 99809..100957 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005476
References cited on this page View Complete Literature Guide for MSN1
1) Estruch F and Carlson M  (1990) Increased dosage of the MSN1 gene restores invertase expression in yeast mutants defective in the SNF1 protein kinase. Nucleic Acids Res 18(23):6959-64
2) Eide D and Guarente L  (1992) Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. J Gen Microbiol 138(2):347-54
3) Lambrechts MG, et al.  (1996) A multicopy suppressor gene, MSS10, restores STA2 expression in Saccharomyces cerevisiae strains containing the STA10 repressor gene. Curr Genet 29(6):523-9
4) Lambrechts MG, et al.  (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 93(16):8419-24
5) Gimeno CJ and Fink GR  (1994) Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14(3):2100-12
6) Rep M, et al.  (1999) Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p. Mol Cell Biol 19(8):5474-85
7) Chang KS, et al.  (2003) The putative transcriptional activator MSN1 promotes chromium accumulation in Saccharomyces cerevisiae. Mol Cells 16(3):291-6
8) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76