MSH5/YDL154W Summary Help

Standard Name MSH5 1
Systematic Name YDL154W
Feature Type ORF, Verified
Description Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans (2, 3, 4)
Name Description MutS Homolog 1
Chromosomal Location
ChrIV:178334 to 181039 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MSH5 GO evidence and references
  View Computational GO annotations for MSH5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
28 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 5
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Positive Genetic: 2
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 901
Molecular Weight (Da) 102,208
Isoelectric Point (pI) 4.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:178334 to 181039 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2706 178334..181039 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002313
References cited on this page View Complete Literature Guide for MSH5
1) Hollingsworth NM, et al.  (1995) MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes Dev 9(14):1728-39
2) Winand NJ, et al.  (1998) Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. Genomics 53(1):69-80
3) Pochart P, et al.  (1997) Conserved properties between functionally distinct MutS homologs in yeast. J Biol Chem 272(48):30345-9
4) Bawa S and Xiao W  (2003) A single amino acid substitution in MSH5 results in DNA alkylation tolerance. Gene 315():177-82