MSH4/YFL003C Summary Help

Standard Name MSH4
Systematic Name YFL003C
Feature Type ORF, Verified
Description Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein (1, 2)
Name Description MutS Homolog
Chromosomal Location
ChrVI:137157 to 134521 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MSH4 GO evidence and references
  View Computational GO annotations for MSH4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
89 total interaction(s) for 87 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 59
  • Phenotypic Enhancement: 3
  • Positive Genetic: 7
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 878
Molecular Weight (Da) 99,224
Isoelectric Point (pI) 7.24
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:137157 to 134521 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): ARS605
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2637 137157..134521 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001891
References cited on this page View Complete Literature Guide for MSH4
1) Ross-Macdonald P and Roeder GS  (1994) Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell 79(6):1069-80
2) Novak JE, et al.  (2001) The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distribution. Genetics 158(3):1013-25