Standard Name	MSA1 1
Systematic Name	YOR066W
Alias	YOR29-17
Feature Type	ORF, Verified
Description	Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Mbf and Sbf Associated 1

Chromosomal Location	ChrXV:449436 to 451325 | ORF Map | GBrowse

	View Computational GO annotations for MSA1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	G1/S transition of mitotic cell cycle (IMP) regulation of cell size (IGI, IMP) regulation of transcription involved in G1 phase of mitotic cell cycle (IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	resistance to sirolimus: increased
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal cell cycle progression in S phase: abnormal cellular morphology: abnormal critical cell size at START (G1 cell-size checkpoint): decreased
repressible	critical cell size at START (G1 cell-size checkpoint): increased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	53 total interaction(s) for 38 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 5 Dosage Lethality: 1 Dosage Rescue: 4 Negative Genetic: 25 Positive Genetic: 1 Synthetic Growth Defect: 5 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:449436 to 451325 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1890 449436..451325 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005592