MRS4/YKR052C Summary Help

Standard Name MRS4 1
Systematic Name YKR052C
Feature Type ORF, Verified
Description Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Mitochondrial RNA Splicing 6
Chromosomal Location
ChrXI:533464 to 532550 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All MRS4 GO evidence and references
  View Computational GO annotations for MRS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Classical genetics
Large-scale survey
67 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • PCA: 2
  • Protein-RNA: 1

Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 7
  • Negative Genetic: 30
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 6
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 3

Expression Summary
Length (a.a.) 304
Molecular Weight (Da) 33,307
Isoelectric Point (pI) 8
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXI:533464 to 532550 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..915 533464..532550 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000001760
References cited on this page View Complete Literature Guide for MRS4
1) Wiesenberger G, et al.  (1991) MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family. J Mol Biol 217(1):23-37
2) Muhlenhoff U, et al.  (2003) A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. J Biol Chem 278(42):40612-20
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Froschauer EM, et al.  (2009) The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane. Biochim Biophys Acta 1788(5):1044-50
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Kreike J, et al.  (1986) Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Curr Genet 11(3):185-91